Eliquis (Apixaban) 5mg prevent blood clots in your veins after a hip or knee replacement surgery. After an operation you are at an increased risk of getting blood clots.
Eliquis 5mg (Apixaban) prevent stroke and blood clots in a condition called atrial fibrillation, which is a type of abnormal heart rhythm. With atrial fibrillation, part of the heart does not beat the way it should. This can lead to blood clots forming and increase your risk of having a stroke.
How it works
Eliquis (Apixaban) 5mg belongs to a class of drugs called anticoagulants, specifically factor Xa blockers. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.
Eliquis (Apixaban) 5mg is a blood thinner and helps to prevent blood clots from forming in your body. It does this by blocking the substance factor Xa, which in turn decreases the amount of the enzyme thrombin in your blood. Thrombin is a substance that causes platelets in your blood to stick to one another, causing clots to form. When thrombin is decreased, this prevents a clot (thrombus) from forming in your body.
Dosage and Administration
Reduction of Risk of Stroke and Systemic Embolism in Patients with Nonvalvular Atrial Fibrillation
The recommended dose of ELIQUIS for most patients is 5 mg taken orally twice daily.
The recommended dose of ELIQUIS is 2.5 mg twice daily in patients with at least two of the following characteristics:
age ≥ 80 years
body weight ≤ 60 kg
serum creatinine ≥ 1.5 mg/dL
Prophylaxis of Deep Vein Thrombosis Following Hip or Knee Replacement Surgery
The recommended dose of ELIQUIS is 2.5 mg taken orally twice daily. The initial dose should be taken 12 to 24 hours after surgery.
In patients undergoing hip replacement surgery, the recommended duration of treatment is 35 days.
In patients undergoing knee replacement surgery, the recommended duration of treatment is 12 days.
Treatment Of DVT And PE
The recommended dose of ELIQUIS is 10 mg taken orally twice daily for the first 7 days of therapy. After 7 days, the recommended dose is 5 mg taken orally twice daily.
Eliquis (Apixaban) 5mg side effects
Eliquis 5mg oral tablet doesn’t cause drowsiness, but it can cause other side effects.
More common side effects
The more common side effects that can occur with apixaban include:
Bleeding. Symptoms may include:
bruising more easily
heavy menstrual bleeding
bleeding of your gums when you brush your teeth
If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor.
Serious side effects
Serious side effects and their symptoms can include the following:
Serious bleeding. This can be deadly, symptoms can include:
unexpected bleeding or bleeding that lasts a long time (including unusual bleeding from your gums, nosebleeds that happen often, or heavy menstrual bleeding)
bleeding that is severe or uncontrollable
red, pink, or brown-colored urine
red- or black-colored, tarry stools
coughing up blood or blood clots
vomiting blood or vomit that looks like coffee grounds
unexpected pain or swelling
headaches, dizziness, or weakness
Spinal or epidural blood clots. If you take apixaban and have another drug injected into your spine, or if you have a spinal puncture, you may be at risk of a spinal or epidural blood clot. This can lead to permanent paralysis. Symptoms can include:
tingling, numbness, or muscle weakness, especially in your legs and feet
loss of control of your bladder or bowels
Abciximab: (Major) The concomitant use of apixaban and platelet inhibitors (e.g, aspirin) may increase the risk of bleeding. In the ARISTOTLE trial (comparative trial of apixaban and warfarin in patients with nonvalvular atrial fibrillation), concomitant use of aspirin increased the bleeding risk of apixaban from 1.8%/year to 3.4%/year. If given concomitantly, patients should be educated about the signs and symptoms of bleeding and be instructed to report them immediately or go to an emergency room.
Acetaminophen; Aspirin, ASA; Caffeine: (Major) Large doses of salicylates (>= 3-4 g/day) can cause hypoprothrombinemia, an additional risk factor for bleeding. Patients taking large doses of salicylates and apixaban should be monitored closely for bleeding.
Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine: (Major) Large doses of salicylates (>= 3-4 g/day) can cause hypoprothrombinemia, an additional risk factor for bleeding. Patients taking large doses of salicylates and apixaban should be monitored closely for bleeding.
Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide: (Major) Large doses of salicylates (>= 3-4 g/day) can cause hypoprothrombinemia, an additional risk factor for bleeding. Patients taking large doses of salicylates and apixaban should be monitored closely for bleeding.